Polynucleotides vs. Skin Boosters: What’s the Difference?

Dec 16

3 min read

The aesthetics world is constantly evolving, with new treatments promising radiant, rejuvenated skin. Two buzzworthy treatments making waves are polynucleotides and skin boosters. But what exactly are they? And how do they compare? At ReVitafy Aesthetics, we’re all about evidence-based treatments, so let’s dive into the science and help you decide which is right for your skin.

What Are Polynucleotides?

Polynucleotides are naturally occurring biopolymers composed of nucleotides, the building blocks of DNA and RNA. In aesthetics, polynucleotides are derived from purified salmon DNA (don’t worry, it’s highly refined and safe for human use). They work on a cellular level to:

Stimulate tissue regeneration: Repair damaged skin by enhancing fibroblast activity.
Improve hydration: Act like a sponge to retain moisture.
Fight oxidative stress: Neutralize free radicals to slow skin aging.

Essentially, polynucleotides don’t just address superficial skin concerns—they focus on repairing and regenerating the skin’s structure from within.

What Are Skin Boosters?

Skin boosters, such as Profhilo and Restylane Vital, are hyaluronic acid-based treatments. Hyaluronic acid (HA) is a naturally occurring molecule in the skin that holds water, giving you that dewy, plump look. Skin boosters are injected into the skin to:

Enhance hydration: Flood the skin with moisture.
Improve elasticity: Boost collagen and elastin production.
Smooth fine lines: Subtly reduce the appearance of wrinkles.

Unlike dermal fillers, skin boosters don’t add volume. Instead, they focus on improving skin quality and texture.

How Do Polynucleotides Compare to Skin Boosters?

Both treatments improve skin health, but they work differently and have unique benefits. Here’s how they compare:

Feature	Polynucleotides	Skin Boosters
Main Ingredient	DNA/RNA fragments (polynucleotides)	Hyaluronic acid
Mode of Action	Tissue repair and regeneration	Intense hydration and collagen stimulation
Target Concerns	Skin damage, scarring, aging, dullness	Dehydration, fine lines, loss of elasticity
Longevity	6–12 months (varies by product)	6 months (recommended 2–3 treatments/year)
Downtime	Minimal, with potential for mild redness	Minimal, with occasional mild swelling
Best For	Damaged, aging, or scarred skin	Dehydrated, dull, or slightly lax skin

What Does the Evidence Say?

Polynucleotides are supported by studies demonstrating their regenerative effects. Research shows they:

Increase fibroblast activity, essential for collagen production.
Improve skin elasticity and hydration over time.
Help with wound healing and reducing inflammation, making them ideal for acne scarring or post-laser treatments.

Skin boosters are backed by robust evidence for their ability to enhance hydration and smooth fine lines. Hyaluronic acid treatments:

Restore moisture levels deep in the dermis.
Encourage collagen and elastin synthesis for firmer skin.
Offer immediate and visible improvements in skin radiance.

Both treatments have been shown to be safe and effective, but their mechanisms of action and long-term effects differ.

Which One Is Right for You?

Your choice depends on your skin’s needs and goals:

Polynucleotides are ideal if you’re looking to repair damage, treat scars, or regenerate aging skin.
Skin boosters are perfect for a hydration boost, smoothing fine lines, and achieving a luminous glow.

At ReVitafy Aesthetics, we’ll work with you to create a personalised treatment plan based on your unique skin concerns.

The Verdict

Polynucleotides and skin boosters both offer incredible benefits for improving skin health, but they shine in different areas. By understanding the science behind these treatments, you can make an informed decision about what’s best for your skin.

💡 Ready to rejuvenate your skin? Book a consultation with us today and let’s get started on your glow-up journey!